Scientific Publications

Cordero, J.; Swaminathan, G.; Rogel-Ayala, D. G.; Rubio, K.; Elsherbiny, A.; Mahmood, S.; Szymanski, W.; Graumann, J.; Braun, T.; Guenther, S. et al.; Dobreva, G.; Barreto, G.: Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription. NATURE COMMUNICATIONS 15 (1), 10711 (2024)

Kothalawala, S. D.; Guenther, S.; Schuppe, H.-C.; Pilatz, A.; Wagenlehner, F.; Kliesch, S.; O'Donnell, L.; Fietz, D.: Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis. REPRODUCTIVE MEDICINE AND BIOLOGY 23 (1), e12616 (2024)

Liu, X.; Gu, L.; Hao, C.; Xu, W.; Leng, F.; Zhang, P.; Li, W.: Systematic assessment of structural variant annotation tools for genomic interpretation. LIFE SCIENCE ALLIANCE 8 (3), e202402949 (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Wang, Z.-Y.; Mehra, A.; Wang, Q.-C.; Gupta, S.; da Silva, A. R.; Juan, T.; Guenther, S.; Looso, M.; Detleffsen, J.; Stainier, D. Y. R. et al.; Marin-Juez, R.: flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. DEVELOPMENT 151 (23), dev203028 (2024)

Baxan, N.; Zhao, L.; Ashek, A.; Niglas, M.; Wang, D.; Khassafi, F.; Sabrin, F.; Dubois, O.; Chen, C.-N.; Pullamsetti, S. S. et al.; Wilkins, M.; Zhao, L.: Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension. SCIENTIFIC REPORTS 14 (1), 29774 (2024)

Baxan, N.; Zhao, L.; Ashek, A.; Niglas, M.; Wang, D.; Khassafi, F.; Sabrin, F.; Dubois, O.; Chen, C.-N.; Pullamsetti, S. S. et al.; Wilkins, M.; Zhao, L.: Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension. SCIENTIFIC REPORTS 14 (1), 29774 (2024)

Seidel, L.-M.; Thudium, J.; Smith, C.; Sapehia, V.; Sommer, N.; Wujak, M.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Novoyatleva, T.: Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH. CELLULAR SIGNALLING 127, 111527 (2024)

Seidel, L.-M.; Thudium, J.; Smith, C.; Sapehia, V.; Sommer, N.; Wujak, M.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Novoyatleva, T.: Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH. CELLULAR SIGNALLING 127, 111527 (2024)

Yoshida, T.; Yoshida, S.; Inukai, K.; Kato, K.; Yura, Y.; Hattori, T.; Taki, K.; Enomoto, A.; Ohashi, K.; Okumura, T. et al.; Ouchi, N.; Kawase, H.; Wettschureck, N.; Offermanns, S.; Murohara, T.; Takefuji, M.: ALPK2 prevents cardiac diastolic dysfunction in heart failure with preserved ejection fraction. FASEB JOURNAL 38 (22), e70192 (2024)

Zierden, M.; Berghausen, E. M.; Gnatzy-Feik, L.; Millarg, C.; Picard, F. S. R.; Kiljan, M.; Geissen, S.; Polykratis, A.; Zimmermann, L.; Nies, R. J. et al.; Pasparakis, M.; Baldus, S.; Valasarajan, C.; Pullamsetti, S. S.; Winkels, H.; Vantler, M.; Rosenkranz, S.: Hematopoietic PI3KS deficiency aggravates murine atherosclerosis through impairment of Tregs. JCI INSIGHT 9 (22), e155626 (2024)

Teichmann, T.; Pflueger-Mueller, B.; Gimenez, V. M. M.; Sailer, F.; Dirks, H.; Zehr, S.; Warwick, T.; Brettner, F.; Munoz-Tello, P.; Zimmer, A. et al.; Tegeder, I.; Thomas, D.; Gurke, R.; Guenther, S.; Heering, J.; Proschak, E.; Geisslinger, G.; Bibli, I.-S.; zu Heringdorf, D. M.; Manucha, W.; Windbergs, M.; Knapp, S.; Weigert, A.; Leisegang, M. S.; Kojetin, D.; Brandes, R. P.: The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. BRITISH JOURNAL OF PHARMACOLOGY (2024)

Prieto-Garcia, C.; Matkovic, V.; Mosler, T.; Li, C.; Liang, J.; Oo, J. A.; Haidle, F.; Macinkovic, I.; Cabrera-Orefice, A.; Berkane, R. et al.; Giuliani, G.; Xu, F.; Jacomin, A.-C.; Tomaskovic, I.; Basoglu, M.; Hoffmann, M. E.; Rathore, R.; Cetin, R.; Boutguetait, D.; Bozkurt, S.; Canas, M. C. H.; Keller, M.; Busam, J.; Shah, V. J.; Wittig, I.; Kaulich, M.; Beli, P.; Galej, W. P.; Ebersberger, I.; Wang, L.; Muench, C.; Stolz, A.; Brandes, R. P.; Tse, W. K. F.; Eimer, S.; Stainier, D. Y. R.; Legewie, S.; Zarnack, K.; Mueller-McNicoll, M.; Dikic, I.: Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy. SCIENCE 386 (6723), pp. 768 - 776 (2024)

Hebchen, D. M.; Schader, T.; Spaeth, M.; Mueller, N.; Graumann, J.; Schroeder, K.: NoxO1 regulates EGFR signaling by its interaction with Erbin. REDOX BIOLOGY 77, 103396 (2024)

Guignabert, C.; Aman, J.; Bonnet, S.; Dorfmueller, P.; Olschewski, A. J.; Pullamsetti, S.; Rabinovitch, M.; Schermuly, R. T.; Humbert, M.; Stenmark, K. R.: Pathology and pathobiology of pulmonary hypertension: current insights and future directions. EUROPEAN RESPIRATORY JOURNAL 64 (4), 2401095 (2024)

Guignabert, C.; Aman, J.; Bonnet, S.; Dorfmueller, P.; Olschewski, A. J.; Pullamsetti, S.; Rabinovitch, M.; Schermuly, R. T.; Humbert, M.; Stenmark, K. R.: Pathology and pathobiology of pulmonary hypertension: current insights and future directions. EUROPEAN RESPIRATORY JOURNAL 64 (4), 2401095 (2024)

Gamez-Garcia, A.; Espinosa-Alcantud, M.; Bueno-Costa, A.; Alari-Pahissa, E.; Marazuela-Duque, A.; Thackray, J. K.; Ray, C.; Berenguer, C.; Kumari, P.; Bech, J. J. et al.; Braun, T.; Ianni, A.; Tischfield, J. A.; Serrano, L.; Esteller, M.; Sardina, J. L.; de la Torre, C.; Sigvardsson, M.; Vazquez, B. N.; Vaquero, A.: A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5. NATURE IMMUNOLOGY (2024)

Li, X.; Kempf, S.; Lagos, F. D.; Ukan, U.; Popp, R.; Hu, J.; Froemel, T.; Guenther, S.; Weigert, A.; Fleming, I.: A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling. ISCIENCE 27 (10), 110938 (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)