Publications of Mohamad Wessam Alnouri

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Hernandez-Olmos, V.; Heering, J.; Ildefeld, N.; Ehrler, J. H. M.; Kaps, A.; Rajkumar, R.; Marinescu, B.; Kaiser, A.; Macinkovic, I.; Elewa, M. A. F. et al.; Alnouri, M. W.; Elson, L.; Schubert-Zsilavecz, M.; Kallenborn-Gerhardt, W.; Schmidtko, A.; Mueller, S.; Offermanns, S.; Steinhilber, D.; Weigert, A.; Proschak, E.: Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. JOURNAL OF MEDICINAL CHEMISTRY 68 (2), pp. 1195 - 1221 (2025)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)

Hernandez-Olmos, V.; Heering, J.; Marinescu, B.; Schermeng, T.; Ivanov, V. V.; Moroz, Y. S.; Nevermann, S.; Mathes, M.; Ehrler, J. H. M.; Alnouri, M. W. et al.; Wolf, M.; Haydo, A. S.; Schmachtel, T.; Zaliani, A.; Ho''fner, G.; Kaiser, A.; Schubert-Zsilavecz, M.; Beck-Sickinger, A. G.; Offermanns, S.; Gribbon, P.; Rieger, M. A.; Merk, D.; Sisignano, M.; Steinhilber, D.; Proschak, E.: Development of a Potent and Selective G2A (GPR132) Agonist. JOURNAL OF MEDICINAL CHEMISTRY (2024)

Wang, T.; Shao, J.; Shamit, K.; Alnouri, M. W.; Carvalho, J.; Guenther, S.; Krasel , C.; Murphy, K. T.; Buenemann, M.; Offermanns, S. et al.; Wettschureck, N.: Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction. CIRCULATION RESEARCH 134 (10), pp. 1259 - 1275 (2024)

Marx, D.; Alnouri, M. W.; Clemens, S.; Gedschold, R.; Riedel, Y.; Al Hamwi, G.; Pillaiyar, T.; Hockemeyer, J.; Namasivayam, V.; Mueller, C. E.: Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4). JOURNAL OF MEDICINAL CHEMISTRY 66 (23), pp. 15674 - 15698 (2023)

Wedel, S.; Hahnefeld, L.; Alnouri, M. W.; Offermanns, S.; Hausch, F.; Geisslinger, G.; Sisignano, M.: The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (22), 14274 (2022)

Schebb, N. H.; Kuehn, H.; Kahnt, A. S.; Rund, K. M.; O'Donnell, V. B.; Flamand, N.; Peters-Golden, M.; Jakobsson, P.-J.; Weylandt, K. H.; Rohwer, N. et al.; Murphy, R. C.; Geisslinger, G.; FitzGerald, G. A.; Hanson, J.; Dahlgren, C.; Alnouri, M. W.; Offermanns, S.; Steinhilber, D.: Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? FRONTIERS IN PHARMACOLOGY 13, 838782 (2022)

Le Mercier, A.; Bonnavion, R.; Yu, W.; Alnouri, M. W.; Ramas, S.; Zhang, Y.; Jaeger, Y.; Roquid, K. A.; Jeong, H.-W.; Sivaraj, K. K. et al.; Cho, H.; Chen, X.; Strilic, B.; Sijmonsma, T.; Adams, R.; Schroeder, T.; Rieger, M. A.; Offemanns, S.: GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118 (17), e2021596118 (2021)