Publications of Rajkumar Savai

Weiss, L. M.; Warwick, T.; Zehr, S.; Guenther, S.; Wolf, S.; Schmachtel, T.; Ponce, J. I.; Palfi, K.; Teichmann, T.; Schneider, A. et al.; Stoetzel, J.; Knapp, S.; Weigert, A.; Savai, R.; Rieger, M. A.; Oellerich, T.; Wittig, I.; Oo, J. A.; Brandes, R. P.; Leisegang, M. S.: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. COMMUNICATIONS BIOLOGY 7 (1), 1131 (2024)

Cekay, M.; Arndt, P. F.; Franken, J. K.; Wilhelm, J.; Pullamsetti, S. S.; Roller, F. C.; Sommer, N.; Askevold, I.; Luedecke, G.; Langer, C. et al.; Stein, M.; Zeppernick, F.; Tello, K.; Sibelius, U.; Grimminger, F.; Seeger, W.; Savai, R.; Eul, B.: Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer. BMJ OPEN RESPIRATORY RESEARCH 11 (1), e001916 (2024)

Flaxman, H. A.; Chrysovergi, M.-A.; Han, H.; Kabir, F.; Lister, R. T.; Chang, C.-F.; Yvon, R.; Black, K. E.; Weigert, A.; Savai, R. et al.; Egea-Zorrilla, A.; Pardo-Saganta, A.; Lagares, D.; Woo, C. M.: Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B. JCI INSIGHT 9 (15), e171162 (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Budczies, J.; Romanovsky, E.; Kirchner, M.; Neumann, O.; Blasi, M.; Schnorbach, J.; Shah, R.; Bozorgmehr, F.; Savai, R.; Stiewe, T. et al.; Peters, S.; Schirmacher, P.; Thomas, M.; Kazdal, D.; Christopoulos, P.; Stenzinger, A.: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma. BRITISH JOURNAL OF CANCER (2024)

Turkowski, K.; Herzberg, F.; Guenther, S.; Weigert, A.; Haselbauer, T.; Fink, L.; Brunn, D.; Grimminger, F.; Seeger, W.; Sueltmann, H. et al.; Stiewe, T.; Pullamsetti, S. S.; Savai, R.: miR-147b mediated suppression of DUSP8 promotes lung cancer progression. ONCOGENE (2024)

Baig, M. S.; Barmpoutsi, S.; Bharti, S.; Weigert, A.; Hirani, N.; Atre, R.; Khabiya, R.; Sharma, R.; Sarup, S.; Savai, R.: Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look. FRONTIERS IN IMMUNOLOGY 15, 1355012 (2024)

Eichhorn, F.; Weigert, A.; Nandigama, R.; Klotz V, L.; Kriegsmann, M.; Allgaeuer, M.; Muley, T.; Christopoulos, P.; Savai, R.; Eichhorn, M. E. et al.; Winter, H.: Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non-Small-Cell Lung Cancer. CLINICAL LUNG CANCER 24 (8) (2023)

Hirani, D. V.; Thielen, F.; Mansouri, S.; Danopoulos, S.; Vohlen, C.; Haznedar-Karakaya, P.; Mohr, J.; Wilke, R.; Selle, J.; Grosch, T. et al.; Mizik, I.; Odenthal, M.; Alvira, C. M.; Kuiper-Makris, C.; Pryhuber, G. S.; Pallasch, C.; van Koningsbruggen-Rietschel, S.; Al-Alam, D.; Seeger, W.; Savai, R.; Doetsch, J.; Alcazar, M. A. A.: CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. INFLAMMATION AND REGENERATION 43 (1), 52 (2023)

Seker-Cin, H.; Tay, T. K. Y.; Kazdal, D.; Kluck, K.; Ball, M.; Neumann, O.; Winter, H.; Herth, F.; Heussel, C.-P.; Savai, R. et al.; Schirmacher, P.; Thomas, M.; Budczies, J.; Allgaeuer, M.; Christopoulos, P.; Stenzinger, A.; Volckmar, A.-L.: Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications. LUNG CANCER 184, 107317 (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Goldschmid, H.; Kluck, K.; Ball, M.; Kirchner, M.; Allgaeuer, M.; Winter, H.; Herth, F.; Heussel, C.-P.; Pullamsetti, S. S.; Savai, R. et al.; Yong, T. T. K.; Schirmacher, P.; Peters, S.; Thomas, M.; Christopoulos, P.; Budczies, J.; Stenzinger, A.; Kazdal, D.: Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naive lung adenocarcinomas. LUNG CANCER 180, 107212 (2023)

Nayakanti, S. R.; Friedrich, A.; Sarode, P.; Jafari, L.; Maroli, G.; Boehm, M.; Bourgeois, A.; Grobs, Y.; Khassafi, F.; Kuenne, C. et al.; Guenther, S.; Dabral, S.; Wilhelm, J.; Weiss, A.; Wietelmann, A.; Kojonazarov, B.; Janssen, W.; Looso, M.; de Man, F.; Provencher, S.; Tello, K.; Seeger, W.; Bonnet, S.; Savai, R.; Schermuly, R.; Pullamsetti, S. S.: Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH 132 (11), pp. 1468 - 1485 (2023)

Lutz, V.; Hellmund, V. M.; Picard, F. S. R.; Raifer, H.; Ruckenbrod, T.; Klein, M.; Bopp, T.; Savai, R.; Duewell, P.; Keber, C. U. et al.; Weigert, A.; Chung, H.-R.; Buchholz, M.; Menke, A.; Gress, T. M.; Huber, M.; Bauer, C.: IL18 Receptor Signaling Regulates Tumor-Reactive CD8(+) T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model. CANCER IMMUNOLOGY RESEARCH 11 (4), pp. 421 - 434 (2023)

Spella, M.; Ntaliarda, G.; Skiadas, G.; Lamort, A.-S.; Vreka, M.; Marazioti, A.; Lilis, I.; Bouloukou, E.; Giotopoulou, G. A. A.; Pepe, M. A. A. et al.; Weiss, S. A. I.; Petrera, A.; Hauck, S. M. M.; Koch, I.; Lindner, M.; Hatz, R. A. A.; Behr, J.; Arendt, K. A. M.; Giopanou, I.; Brunn, D.; Savai, R.; Jenne, D. E. E.; de Chateau, M.; Yull, F. E. E.; Blackwell, T. S. S.; Stathopoulos, G. T. T.: Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1 beta via Versican and Mononuclear IKK beta. CANCERS 15 (6), 1866 (2023)

Picard, F. S. R.; Lutz, V.; Brichkina, A.; Neuhaus, F.; Ruckenbrod, T.; Hupfer, A.; Raifer, H.; Klein, M.; Bopp, T.; Pfefferle, P. I. et al.; Savai, R.; Prinz, I.; Waisman, A.; Moos, S.; Chang, H.-D.; Heinrich, S.; Bartsch, D. K.; Buchholz, M.; Singh, S.; Tu, M.; Klein, L.; Bauer, C.; Liefke, R.; Burchert, A.; Chung, H.-R.; Mayer, P.; Gress, T. M.; Lauth, M.; Gaida, M.; Huber, M.: IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. GUT (2023)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)

Merle, N.; Elmshaeuser, S.; Strassheimer, F.; Wanzel, M.; Koenig, A. M.; Funk, J.; Neumann, M.; Kochhan, K.; Helmprobst, F.; Pagenstecher, A. et al.; Nist, A.; Mernberger, M.; Schneider, A.; Braun, T.; Borggrefe, T.; Savai, R.; Timofeev, O.; Stiewe, T.: Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. MOLECULAR CANCER 21 (1), 191 (2022)