Publications of Rajkumar Savai

Solimani, F.; Pollmann, R.; Schmidt, T.; Schmidt, A.; Zheng, X.; Savai, R.; Muehlenbein, S.; Pickert, J.; Eubel, V.; Moebs, C. et al.; Eming, R.; Hertl, M.: Therapeutic Targeting of Th17/Tc17 Cells Leads to Clinical Improvement of Lichen Planus. FRONTIERS IN IMMUNOLOGY 10, 1808 (2019)

Al-Tamari, H. M.; Dabral, S.; Schmall, A.; Sarvari, P.; Ruppert, C.; Paik, J.; DePinho, R. A.; Grimminger, F.; Eickelberg, O.; Guenther, A. et al.; Seeger, W.; Savai, R.; Pullamsetti, S. S.: FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO MOLECULAR MEDICINE 10 (2), pp. 276 - 293 (2018)

Baig, M. S.; Roy, A.; Saqib, U.; Rajpoot, S.; Srivastava, M.; Naim, A.; Liu, D.; Saluja, R.; Faisal, S. M.; Pan, Q. et al.; Turkowski, K.; Darwhekar, G. N.; Savai, R.: Repurposing Thioridazine (TDZ) as an anti-inflammatory agent. SCIENTIFIC REPORTS 8, 12471 (2018)

Brunn, D.; Grimminger, F.; Seeger, W.; Savai, R.: Interferon Regulatory Factor 9 Mediated Regulation of Lung Cancer Progression and Metastasis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Pullamsetti, S. S.; Seeger, W.; Savai, R.: Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension. JOURNAL OF CLINICAL INVESTIGATION 128 (5), pp. 1720 - 1723 (2018)

Saqib, U.; Kelley, T. T.; Panguluri, S. K.; Liu, D.; Savai, R.; Baig, M. S.; Schurer, S. C.: Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets. FRONTIERS IN PHARMACOLOGY 9, 1201 (2018)

Sarode, P.; Zheng, X.; Weigert, A.; Tretyn, A.; Guenther, S.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Savai, R.: Reprogramming of Tumor Associated Macrophages by Modulating Wnt beta-Catenin Signalling in Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Turkowski, K.; Haselbauer, T.; Kaduthanam, S.; Sueltmann, H.; Grimminger, F.; Seeger, W.; Savai, R.: Macrophage and Cancer Cell Crosstalk Regulated MicroRNA 147b Plays a Crucial Role in Lung Cancer Progression. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Kiehl, S.; Zimmermann, T.; Savai, R.; Pullamsetti, S. S.; Seeger, W.; Bartkuhn, M.; Dammann, R. H.: Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer. SCIENTIFIC REPORTS 7, 3896 (2017)

Pullamsetti, S. S.; Kojonazarov, B.; Storn, S.; Gall, H.; Salazar, Y.; Wolf, J.; Weigert, A.; El-Nikhely, N.; Ghofrani, H. A.; Krombach, G. A. et al.; Fink, L.; Gattenlohner, S.; Rapp, U. R.; Schermuly, R. T.; Grimminger, F.; Seeger, W.; Savai, R.: Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk. SCIENCE TRANSLATIONAL MEDICINE 9 (416), eaai9048 (2017)

Pullamsetti, S. S.; Savai, R.: Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 56 (5), pp. 556 - 558 (2017)

Pullamsettit, S. S.; Savai, R.; Seeger, W.; Goncharova, E. A.: From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics Targeting Cell Growth and Proliferation Signaling Hubs. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (4), pp. 425 - 437 (2017)

Savai, R.; Asafova, A.; Zheng, X.; Schmall, A.; Weigert, A.; Pullamsetti, S. S.; Seeger, W.: Circulating Fibrocytes Depletion Results In Reduced Lung Tumor Growth And Metastasis By Modulating Macrophage Phenotype, Angiogenesis And Endothelin System. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Weichand, B.; Popp, R.; Dziumbla, S.; Mora, J.; Strack, E.; Elwakeel, E.; Frank, A.-C.; Scholich, K.; Pierre, S.; Syed, S. N. et al.; Olesch, C.; Ringleb, J.; Oeren, B.; Doering, C.; Savai, R.; Jung, M.; von Knethen, A.; Levkau, B.; Fleming, I.; Weigert, A.; Bruene, B.: S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1 beta. JOURNAL OF EXPERIMENTAL MEDICINE 214 (9), pp. 2695 - 2713 (2017)

Zheng, X.; Sarode, P.; Weigert, A.; Guenther, S.; Chelladurai, P.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Re-Education Of Tumor-Associated Macrophages By Modulating Histone Deacetylases In Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Zheng, X.; Turkowski, K.; Mora, J.; Brne, B.; Seeger, W.; Weigert, A.; Savai, R.: Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. ONCOTARGET 8 (29), pp. 48436 - 48452 (2017)

Dabral, S.; Muecke, C.; Schmoranzer, M.; Valsarajan, C.; Wietelmann, A.; Savai, R.; Seeger, W.; Dammann, R.; Pullamsetti, S. S.: Rassf1a Regulates Ros-Hif Axis In Hypoxia Driven Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 (2016)

Dabral, S.; Muecke, C.; Schmoranzer, M.; Valsarajan, C.; Wietelmann, A.; Savai, R.; Seeger, W.; Dammann, R.; Pullamsetti, S. S.: Rassf1a Regulates Ros-Hif Axis In Hypoxia Driven Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 (2016)

Dabral, S.; Tian, X.; Kojonazarov, B.; Savai, R.; Ghofrani, H. A.; Weissmann, N.; Florio, M.; Sun, J.; Jonigk, D.; Maegel, L. et al.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Schermuly, R. T.: Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL 48 (4), pp. 1137 - 1149 (2016)

Ghanbari, P.; Wheeler, M.; Stubenvoll, A.; Braun, T.; Savai, R.: The role of emerin in coupling Wnt/beta-catenin signalling to genomic instability in cancer. MOLECULAR BIOLOGY OF THE CELL 27 (2016)