Publications
Web of science or google scholar summary
*co-corresponding authors
Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH.
Weiss M, Hettrich S, Hofmann T, Hachim S, Günther S, Braun T*, Boettger T*.
Nucleic Acids Res. 2024 Apr 3:gkae226. doi: 10.1093/nar/gkae226. Online ahead of print. PMID: 38567728
The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males.
Rogala S, Ali T, Melissari MT, Währisch S, Schuster P, Sarre A, Emídio RC, Boettger T, Rogg EM, Kaur J, Krishnan J, Dumbović G, Dimmeler S, Ounzain S, Pedrazzini T, Herrmann BG, Grote P.
Nat Commun. 2023 Nov 2;14(1):7024. doi: 10.1038/s41467-023-42760-y. PMID: 37919291
Aging impairs the neurovascular interface in the heart.
Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klocker N, Kelm M, Schuttler D, Clauss S, Gunther S, Boettger T, Braun T, Bar C, Pham MD, Krishnan J, Hille S, Muller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxan G, Dimmeler S.
Science. 2023 Aug 25;381(6660):897-906. doi: 10.1126/science.ade4961. PMID: 37616346
Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.
Wu F, Li X, Looso M, Liu H, Ding D, Günther S, Kuenne C, Liu S, Weissmann N, Boettger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gärtner U, Potente M, Zhou Y, Yuan X, Braun T.
Nat Genet. 2023 Jan;55(1):100-111. doi: 10.1038/s41588-022-01252-3. Epub 2022 Dec 20. PMID: 36539616
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner.
Woods ML, Weiss A, Sokol AM, Graumann J, Boettger T, Richter AM, Schermuly RT, Dammann RH.
Cancer Gene Ther. 2022 Dec;29(12):1975-1987. doi: 10.1038/s41417-022-00513-x PMID: 35902728
Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function.
Klockner I, Schutt C, Gerhardt T, Boettger T*, Braun T*.
Nat Commun. 2022 Jun 8;13(1):3180. doi: 10.1038/s41467-022-30778-7. PMID: 35676269
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.
Uenaka M, Yamashita E, Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, Ishii M.
Nat Commun. 2022 Feb 24;13(1):1066. doi: 10.1038/s41467-022-28673-2. PMID: 35210428
Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
Valussi M, Besser J, Wystub-Lis K, Zukunft S, Richter M, Kubin T, Boettger T*, Braun T*.
Sci Adv. 2021 Oct 15;7(42):eabi6648. doi: 10.1126/sciadv.abi6648. Epub 2021 Oct 13. PMID: 34644107
BMP9 and BMP10 act directly on vascular smooth muscle cells for generation and maintenance of the contractile state.
Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T
Circulation. 2021 Apr 6;143(14):1394-1410. doi: 10.1161/CIRCULATIONAHA.120.047375. PMID: 33334130
Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
Schutt C, Hallmann A, Hachim S, Klockner I, Valussi M, Atzberger A, Graumann J, Braun T*, Boettger T*.
EMBO J. 2020 Nov 16;39(22):e105098. doi: 10.15252/embj.2020105098. PMID: 32960481
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.
Li M, Nishio SY, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith FM, Cooper LT, Lee MG, Asano M, Boettger T, Krueger M, Wietelmann A, Graumann J, Day BW, Boyd AW, Offermanns S, Kitajiri SI, Usami SI, Nakayama M.
Nat Commun. 2020 Mar 12;11(1):1343. doi: 10.1038/s41467-020-15198-9. PMID: 32165640
RASSF10 Is Frequently Epigenetically Inactivated in Kidney Cancer and Its Knockout Promotes Neoplasia in Cancer Prone Mice.
Richter AM, Woods ML, Küster MM, Walesch SK, Braun T, Boettger T, Dammann RH.
Oncogene. 2020 Feb 11. doi: 10.1038/s41388-020-1195-6. [Epub ahead of print]. PMID: 32047266
Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.
Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM.
Clin Epigenetics. 2019 Dec 4;11(1):182. doi: 10.1186/s13148-019-0774-2. PMID: 31801617
Exploration of physiological and pathophysiological implications of miRNA-143 and miRNA-145 in cerebral arteries.
Christensen ST, Johansson SE, Warfvinge K, Braun T, Boettger T, Edvinsson L, Haanes KA.
J Cardiovasc Pharmacol. 2019 Aug 13. doi: 10.1097/FJC.0000000000000735. PMID: 31425342
Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.
Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G.
J Exp Med. 2019 Jun 3;216(6):1377-1395. doi: 10.1084/jem.20181394.; PMID: 31015297
Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M.
Science. 2019 Apr 12;364(6436):188-193. doi: 10.1126/science.aat0778. PMID: 30975888
Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference.
Bergmaier P, Weth O, Dienstbach S, Boettger T, Galjart N, Mernberger M, Bartkuhn M, Renkawitz R.
Nucleic Acids Res. 2018 Aug 21;46(14):7097-7107. doi: 10.1093/nar/gky483. PMID: 29860503
Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.
Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T*, Braun T*.
Cell Metab. 2018 May 1;27(5):1026-1039.e6. doi: 10.1016/j.cmet.2018.02.022. Epub 2018 Apr 5. PMID: 29606596
Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries.
Holmberg J, Bhattachariya A, Alajbegovic A, Rippe C, Ekman M, Dahan D, Hien TT, Boettger T, Braun T, Swärd K, Hellstrand P, Albinsson S.
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):414-424. doi: 10.1161/ATVBAHA.117.310499. PMID: 29217510
The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells.
Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A.
Front Immunol. 2017 Aug 28;8:1036. doi: 10.3389/fimmu.2017.01036. eCollection 2017. PMID: 28894447
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells.
Byskov K, Boettger T, Ruehle PF, Nielsen NV, Etscheid M, Kanse SM.
Atherosclerosis. 2017 Aug 25;265:133-139. doi: 10.1016/j.atherosclerosis.2017.08.029. PMID: 28881271
MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction.
Dahan D, Hien TT, Tannenberg P, Ekman M, Rippe C, Boettger T, Braun T, Tran-Lundmark K, Tran PK, Swärd K, Albinsson S.
J Vasc Res. 2017 Aug 11;54(4):246-256. doi: 10.1159/000478013. PMID: 28796998
The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth.
Jiménez AP, Traum A, Boettger T, Hackstein H, Richter AM, Dammann RH.
Oncotarget. 2017 May 23. doi: 10.18632/oncotarget.18177. PMID: 28596500
Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.
Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T*, Boettger T*.
EMBO J. 2017 May 2;36(9):1199-1214. doi: 10.15252/embj.201695988. PMID: 28314781
tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation.
Theofel I, Bartkuhn M, Boettger T, Gartner SM, Kreher J, Brehm A, Rathke C.
Biol Open. 2017 Apr 15;6(4):439-448. doi: 10.1242/bio.022467. PMID: 28235844
Elevated glucose levels promote contractile and cytoskeletal gene expression in vascular smooth muscle via Rho/protein kinase C and actin polymerization.
Hien TT, Turczynska KM, Dahan D, Ekman M, Grossi M, Sjögren J, Nilsson J, Braun T, Boettger T, Garcia Vaz E, Stenkula K, Swärd K, Gomez MF, Albinsson S.
J Biol Chem. 2016 Feb 12;291(7):3552-68. doi: 10.1074/jbc.M115.654384. PMID: 26683376
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M.
Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498. PMID: 26735015
Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.
Kraut B, Maier HJ, Kókai E, Fiedler K, Boettger T, Illing A, Kostin S, Walther P, Braun T, Wirth T.
PLoS One. 2015 Nov 5;10(11):e0141591. doi: 10.1371/journal.pone.0141591. PMID: 26539991
Deficient acid handling with distal RTA in the NBCe2 knockout mouse.
Wen D, Yuan Y, Cornelius RJ, Li H, Warner PC, Wang B, Wang-France J, Boettger T, Sansom SC.
Am J Physiol Renal Physiol. 2015 Sep 15 309(6): F523-530. doi: 10.1152/ajprenal.00163.2015. PMID: 26109087.
Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
Bhattachariya A, Dahan D, Ekman M, Boettger T, Braun T, Sward K, Hellstrand P, Albinsson S.
Acta Physiol (Oxf). 2015 Nov 215(3): 133-143. doi: 10.1111/apha.12536. PMID: 26052659.
Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.
Wen D, Yuan Y, Warner PC, Wang B, Cornelius RJ, Wang-France J, Li H, Boettger T, Sansom SC.
Hypertension. 2015 Jul 66(1): 68-74. doi: 10.1161/HYPERTENSIONAHA.115.05394. PMID: 25941340.
Slc5a8, a Na + -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions.
Gurav A, Sivaprakasam S, Bhutia YD, Boettger T, Singh N, Ganapathy V.
Biochem J. 2015 Jul 15 469(2): 267-278. doi: 10.1042/BJ20150242. PMID: 25984582.
Myocardial healing requires Reg3ß-dependent accumulation of macrophages in the ischemic heart.
Lörchner H, Pöling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T.
Nat Med. 2015 Apr 21(4): 353-362. doi: 10.1038/nm.3816. PMID: 25751817
The miR-206/133b cluster is dispensable for development, survival and regeneration of skeletal muscle.
Boettger T*, Wüst S, Nolte H, Braun T*.
Skelet Muscle. 2014 4(1): 23. doi: 10.1186/s13395-014-0023-5. PMID: 25530839
MiRNA-1/133a Clusters Regulate Adrenergic Control of Cardiac Repolarization.
Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T*, Boettger T*.
PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449. PMID: 25415383
Induction of angiotensin converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.
Dahan D, Ekman M, Larsson-Callerfelt AK, Turczynska K, Boettger T, Braun T, Swärd K, Albinsson S.
Am J Physiol Cell Physiol. 2014 Dec 15 307(12): C1093-1101. doi: 10.1152/ajpcell.00250.2014. PMID: 25273883
tBRD-1 Selectively Controls Gene Activity in the Drosophila Testis and Interacts with Two New Members of the Bromodomain and Extra-Terminal (BET) Family.
Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner SM, Leser K, Awe S, Schipper M, Renkawitz-Pohl R, Rathke C.
PLoS ONE. 2014 9(9): e108267. doi: 10.1371/journal.pone.0108267. PMID: 25251222
Myostatin regulates energy homeostasis in the heart and prevents heart failure.
Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Krüger M, Boettger T, Borchardt T, Braun T.
Circ Res. 2014 Jul 7 115(2): 296-310. doi: 10.1161/CIRCRESAHA.115.304185. PMID: 24807786
Hmga2 is required for canonical WNT signaling during lung development.
Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T, Barreto G.
BMC Biol. 2014 12:21. doi: 10.1186/1741-7007-12-21. PMID: 24661562.
Therapeutic targeting of the oncostatin M receptor-ß prevents inflammatory heart failure.
Pöling J, Gajawada P, Richter M, Lörchner H, Polyakova V, Kostin S, Shin J, Boettger T, Walther T, Rees W, Wietelmann A, Warnecke H, Kubin T, Braun T.
Basic Res Cardiol. 2014 Jan 109(1): 396. doi: 10.1007/s00395-013-0396-3. PMID: 24292852
Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.
Pohjoismäki JL, Williams SL, Boettger T, Goffart S, Kim J, Suomalainen A, Moraes CT, Braun T.
Proc Natl Acad Sci U S A. 2013 Nov 26 110(48): 19408-19413. doi: 10.1073/pnas.1303046110. PMID: 24218554.
Quantitative proteome analysis of alveolar type II cells revealed a connection of integrin receptor subunits beta 2/6 and WNT signaling.
Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto G.
J Proteome Res. 2012 Oct 31 12(12):5598-608. doi: 10.1021/pr400573k. PMID: 24175614
miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.
Wystub K, Besser J, Bachmann A, Boettger T*, Braun T*.
PLoS Genet. 2013 Sep 9(9): e1003793. doi: 10.1371/journal.pgen.1003793. PMID: 24068960.
Molecular Mechanism of SLC5A8-Inactivation in Breast Cancer.
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M.
Mol Cell Biol. 2013 Oct 33(19): 3920-3935. doi: 10.1128/MCB.01702-12. PMID: 23918800.
AMP-Activated Protein Kinase Regulates Endothelial Cell Angiotensin-Converting Enzyme Expression via p53 and the Post-Transcriptional Regulation of microRNA-143/145.
Kohlstedt K, Trouvain C, Boettger T, Shi L, Fisslthaler B, Fleming I.
Circ Res. 2013 Apr 12 112(8): 1150-1158. doi: 10.1161/CIRCRESAHA.113.301282. PMID: 23476055
Induction of the cystine/glutamate exchanger slc7a11 in retinal pigment epithelial cells by the anti-psoriatic drug monomethylfumarate.
Ananth S, Babu E, Veeranan-Karmegam R, Bozard Baldowski BR, Boettger T, Martin PM.
Invest Ophthalmol Vis Sci. 2013 Mar 54(3): 1592-1602. doi: 10.1167/iovs.12-11289. PMID: 23404113
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.
Günther K, Rust M, Leers J, Boettger T, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R.
Nucleic Acids Res. 2013 Mar 1 41(5): 3010-3021. doi: 10.1093/nar/gkt035. PMID: 2336146
A G13-Mediated Signaling Pathway is Required for Pressure Overload-Induced Cardiac Remodeling and Heart Failure.
Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N.
Circulation. 2012 Oct 16 126(16): 1972-1982. doi: 10.1161/CIRCULATIONAHA.112.109256. PMID: 22972902
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
Yang J, Bücker S, Jungblut B, Böttger T, Cinnamon Y, Tchorz J, Müller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T.
Cardiovasc Res. 2012 Nov 1 96(2): 276-285. doi: 10.1093/cvr/cvs250. PMID: 22865640
Cardiomyocyte-specific IkappaB kinase (IKK)/NF-kappaB activation induces reversible inflammatory cardiomyopathy and heart failure.
Maier HJ, Schips TG, Wietelmann A, Krüger M, Brunner C, Sauter M, Klingel K, Böttger T, Braun T, Wirth T.
Proc Natl Acad Sci U S A. 2012 Jul 17 109(29): 11794-11799. doi: 10.1073/pnas.1116584109. PMID: 22753500
Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.
Pohjoismäki JL, Boettger T, Liu Z, Goffart S, Szibor M, Braun T.
Nucleic Acids Res. 2012 Aug 1 40(14): 6595-6607. doi: 10.1093/nar/gks301. PMID: 22508755
A New Level of Complexity: The Role of MicroRNAs in Cardiovascular Development.
Boettger T*, Braun T*.
Circ Res. 2012 Mar 30 110(7): 1000-1013. doi: 10.1161/CIRCRESAHA.111.247742. PMID: 22461364
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S.
Nat Cell Biol. 2012 14(3): 249-256. doi: 10.1038/ncb2441. PMID: 22327366
The Janus face of OSM mediated cardiomyocyte dedifferentiation during cardiac repair and disease.
Pöling J, Gajawada P, Lörchner H, Polyakowa V, Szibor M, Böttger T, Warnecke H, Kubin T, Braun T.
Cell Cycle. 2012 Feb 1 11(3): 439-445. doi: 10.4161/cc.11.3.19024. PMID: 22262173
On marathons and sprints: an integrated quantitative proteomics and transcriptomics analysis of differences between slow and fast muscle fibers.
Drexler HC, Ruhs A, Konzer A, Mendler L, Bruckskotten M, Looso M, Gunther S, Boettger T, Kruger M and Braun T.
Mol Cell Proteomics. 2012 Jun 11(6): M111 010801. doi: 10.1074/mcp.M111.010801. PMID: 22210690
Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.
Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T*, Boettger T*.
Hum Mol Genet. 2012 Mar 1 21(5): 1025-1036. doi: 10.1093/hmg/ddr533. PMID: 22082831
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.
Nat Cell Biol. 2011 Apr 13(4): 434-446. doi: 10.1038/ncb2211. PMID: 21441927
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.
Babu E, Ananth S, Veeranan-Karmegam R, Coothankandaswamy V, Smith SB, Boettger T, Ganapathy V, Martin PM.
Invest Ophthalmol Vis Sci. 2011 Jul 52(8): 5749-5757. doi: 10.1167/iovs.10-6825. PMID: 21508099
Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.
Kreymborg KG, Uchida S, Gellert P, Schneider A, Boettger T, Voswinckel R, Wietelmann A, Szibor M, Weissmann N, Ghofrani AH, Schermuly R, Schranz D, Seeger W, Braun T.
J Mol Cell Cardiol. 2010 Oct 49(4): 598-605. doi: 10.1016/j.yjmcc.2010.07.014. PMID: 20673770
Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.
Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V.
J Biol Chem. 2010 Sep 3 285(36): 27601-27608. doi: 10.1074/jbc.M110.102947. PMID: 20601425
Cardiac deletion of smyd2 is dispensable for mouse heart development.
Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazz, F, Bottger T, Harvey RP, Tucker PW and Engel FB.
PLoS One. 2010 5(3):e9748. doi: 10.1371/journal.pone.0009748. PMID: 20305823
Slc4a11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria.
Groeger N, Froehlich H, Maier H, Olbrich A, Kostin S, Braun T* and Boettger T*.
J Biol Chem. 2010 May 7 285(19):14467-74. doi: 10.1074/jbc.M109.094680. PMID: 20185830
Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice.
Ruschke K, Ebelt H, Kloting N, Boettger T, Raum K, Bluher M and Braun T.
PLoS ONE. 2009 4(5):e5516. doi: 10.1371/journal.pone.0005516. PMID: 19436734
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.
Boettger T*, Beetz N, Kostin S, Schneider J, Kruger M, Hein L and Braun, T*.
J Clin Invest. 2009 Sep 119(9):2634-47. doi: 10.1172/JCI38864. PMID: 19690389
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T and Bober E.
Circ Res. 2008 Mar 28 102(6):703-10. doi: 10.1161/CIRCRESAHA.107.164558 PMID: 18239138
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.
Frank H, Groger N, Diener M, Becker C, Braun T* and Boettger T*.
J Biol Chem. 2008 Sep 5 283(36):24729-37. doi: 10.1074/jbc.M802681200. PMID: 18562324
Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice.
Ebelt H, Zhang Y, Kohler K, Xu J, Gajawada P, Boettger T, Hollemann T, Muller-Werdan U, Werdan K. and Braun T.
J Mol Cell Cardiol. 2008 Sep 45(3):411-9. doi: 10.1016/j.yjmcc.2008.06.006. PMID: 18634800
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Rust MB, Faulhaber J, Budack MK, Pfeffer C, Maritzen T, Didie M, Beck FX, Boettger T, Schubert R, Ehmke H, Jentsch TJ and Hubner CA.
Circ Res. 2006 Mar 39 8(4):549-56. doi: 10.1161/01.RES.0000204449.83861.22. PMID: 16424367
Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE and Simm A (2005)
Lung Cancer. 2005 Aug 49(2):145-54. doi: 10.1016/j.lungcan.2005.02.006. PMID: 16022908
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
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