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Function of non-coding RNAs in the cardiovascular system

Scientific focus

The progress in annotation of the mammalian genome has identified non-coding RNAs (ncRNAs) to be an important class of molecules. The research of our group focuses on a subclass of ncRNAs, the miRNA molecules, and we are specifically interested to understand the molecular functions of miRNAs in the cardiovascular system (see Boettger et al., 2009, Boettger & Braun 2012, Wystub et al., 2013 and Schweisgut et al., 2017) Some of our findings regarding the miRNA function in the cardiovascular system are summarized below.

In addition to analysis of small non-coding RNAs we currently expand our work to molecular functions of other classes of non-coding RNAs in the cardiovascular system and skeletal muscle.

 

Ion transporters have essential functions in all biological processes. To understand the role of ion transporters in physiology and human disease we are analyzing knock-out mouse models for specific transporters with functions in kidney, inner ear and eye (see Frank et al., 2008, Groeger et al., 2010 or Groeger et al, 2011).

 

Group members

Ina Klockner, Christian Schutt, Sylvia Thomas, Melissa Valussi, Maria Weiß, Stas Wüst

 

Applications for Master- and PhD-student positions are welcome.

Contact

Priv.-Doz. Dr. rer. nat. Thomas Böttger

Dept. I - Cardiac Development and Remodeling

Max Planck Institute for Heart and Lung Research

Ludwigstr. 43

D-61231 Bad Nauheim

Germany

Tel.: +49 (0)6032 705-1115

© 2017 Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim